Optimizing novel implant formulations for the prolonged release of biopharmaceuticals using in vitro and in vivo imaging techniques
Dr. Matthias G. Wacker, Goethe-Universität Frankfurt am Main
Published in: Journal of Controlled Release 235 352 (2016)
Dr. Matthias G. Wacker’s working group produces novel implants loaded with interferon ß-1a and trypsinogen as model proteins, which are applied subcutaneously using a thick needle called a trocar. Protein-heparin-nanocomplexes were then produced from the proteins, which in turn are embedded in methyl cellulose and hyaluronic acid, and after freeze drying, pressed into cylindrical implants. The novel implants would made longer retention times possible as well as elevated concentrations of fluorescent-labelled blood, and present a highly promising path to significantly improve the application of protein-based active ingredients.