Pharmacology and Clinical Medicine

Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain

Dr. Rohini Kuner, Institute of Pharmacology, University of Heidelberg

Prof. Kuner and her team showed in a mouse model that the plexin-B2 receptor and its semaphorin-4C ligand are strongly increased in peripheral sensory neurons in adults under inflammation and contribute to the hyperalgesia that occurs during inflammation. In addition, the ligand is also released by immune cells during inflammation, which has an additional pain-enhancing effect. These results suggest important roles for plexin B2 signaling in sensory function, which may be of therapeutic importance in pathological pain.